Towards eradication of inappropriate therapies for ICD lead failure by combining comprehensive remote monitoring and lead noise alerts.

Towards eradication of inappropriate therapies for ICD lead failure by combining comprehensive remote monitoring and lead noise alerts.

J Cardiovasc Electrophysiol. 2018 Jun 02;:

Authors: Ploux S, Swerdlow CD, Strik M, Welte N, Klotz N, Ritter P, Haïssaguerre M, Bordachar P

Abstract
INTRODUCTION: Recognition of implantable cardioverter defibrillator (ICD) lead malfunction before occurrence of life threatening complications is crucial. We aimed to assess the effectiveness of remote monitoring associated or not with a lead noise alert for early detection of ICD lead failure.
METHODS: From October 2013 to April 2017, a median of 1224 [578-1958] ICD patients were remotely monitored with comprehensive analysis of all transmitted materials. ICD lead failure and subsequent device interventions were prospectively collected in patients with (RMLN) and without (RM) a lead noise alert (Abbott SecureSense™ or Medtronic Lead Integrity alert™) in their remote monitoring system.
RESULTS: During a follow-up of 4457 patient years, 64 lead failures were diagnosed. Sixty-one (95%) of the diagnoses were made before any clinical complication occurred. Inappropriate shocks were delivered in only one patient of each group (3%), with an annual rate of 0.04%. All high voltage conductor failures were identified remotely by a dedicated impedance alert in 10 patients. Pace-sense component failures were correctly identified by a dedicated alert in 77% (17/22) of the RMLN group versus 25% (8/32) of the RM group (p = 0.002). The absence of a lead noise alert was associated with a 16-fold increase in the likelihood of initiating either a shock or ATP (OR: 16.0, 95% CI 1.8-143.3; p = 0.01).
CONCLUSION: ICD remote monitoring with systematic review of all transmitted data is associated with a very low rate of inappropriate shocks related to lead failure. Dedicated noise alerts further reduce inappropriate detection of ventricular arrhythmias. This article is protected by copyright. All rights reserved.

PMID: 29858871 [PubMed - as supplied by publisher]