Plasma markers of oxidative status were associated with increasing continuous cardiometabolic risk scores in healthy students aged 16-20 without central obesity.

Plasma markers of oxidative status were associated with increasing continuous cardiometabolic risk scores in healthy students aged 16-20 without central obesity.

Acta Paediatr. 2018 Apr 29;:

Authors: Koborová I, Gurecká R, Csongová M, Šebek J, Šebeková K

Abstract
AIM: We studied the association between increased cardiometabolic risk and markers of oxidative status and glycation in apparently healthy subjects who did not present with central obesity.
METHODS: From 2011 to 2012, we recruited 2,064 students (53% girls) aged 16-20 years from Western Slovakia. Their continuous metabolic syndrome scores were calculated as a mean of the sum of the z-scores of waist-to-height ratio, mean arterial pressure, triacylglycerols, high-density lipoproteins cholesterol and quantitative insulin sensitivity check index. Plasma markers of protein glycation and oxidation, lipid peroxidation and total antioxidant status were analysed.
RESULTS: In both genders, advanced oxidation protein products increased across the continuous metabolic syndrome score quintiles (p<0.001). Advanced oxidation protein products and fructosamines were significant predictors of the continuous metabolic syndrome score in both genders. Moreover, high-sensitivity C-reactive protein, leukocyte counts and advanced glycation end-products contributed significantly in girls. Triacylglycerols, fructosamines, advanced glycation end-products and total antioxidant capacity correlated significantly with advanced oxidation protein products in both genders.
CONCLUSION: Advanced oxidation protein products may act as inflammatory mediators that contribute to the development of cardiometabolic afflictions. Determining these may provide information related to cardiometabolic risk and represent potential target to reduce or prevent irreversible oxidative stress-induced cellular damage. This article is protected by copyright. All rights reserved.

PMID: 29706023 [PubMed - as supplied by publisher]